At menopause, the production of hormones significantly decreases and the balance of hormones fluctuates. Progesterone is generally prescribed along with estrogen to prevent estrogen dominance and endometrial hyperplasia.

Women may be prescribed other medications or hormones in conjunction with progesterone and estrogen. For example, although testosterone is often thought of as only a male hormone, it is actually also an important hormone for women. A compounding pharmacy can make a formulation that includes estrogen, progesterone, and testosterone in one combination.