Anal fissures are a painful tearing of the thin tissue that lines the anus. The most common symptoms are pain with bowel movements and bleeding. Some anal fissures are minor and will go away without treatment or with simple lifestyle changes like increasing fiber intake. Others can be more persistent and painful and require treatment […]
It is thought that upper dermal mast cells are a part of the pathogenesis of melasma. Pathogenesis describes the manner of the development of a disease. Key treatments for melasma reduce mast cells in the upper layers of the skin (such as tranexamic acid and corticosteroids). Stabilizing mast cells is one possible treatment target for […]
New research on low dose naltrexone for treating a variety of chronic conditions is being published on a monthly basis. Recent research has been done that used low dose naltrexone on patients with fibromyalgia, corneal neuropathic pain, cancer, immunothrombosis in COVID-19, epilepsy, and more. A biopharmaceutical company has released data from their Phase 1 clinical […]
Negatan is a product that is no longer commercially available except through compounding pharmacies. Negatan was the brand name for polyphenol sulfonic acid complex – a medication that is particularly effective for treating oral ulcers. Mouth ulcers, also called canker sores, are a common condition and one that is frequently reported to dentists. There are […]
Transdermal patches allow controlled delivery of medication that is either immediate, administered gradually, or both. There are several reasons why this method of administration may be preferred to an oral form of a drug or a topical cream or gel. Transdermal patches are commercially available in prescription and OTC forms and can also be custom […]
An ingredient that is frequently prescribed by dermatologists but may not be well known by all patients is azelaic acid. There are numerous possible uses in dermatology for azelaic acid including in treatments for acne, rosacea, and melasma. Azelaic acid is a powerful anti-inflammatory and antibacterial that fights acne-causing bacteria, reduces inflammation, and exfoliates the […]
There are many medications that are contraindicated with the use of PDE5 inhibitors. Sildenafil and tadalafil are the most commonly prescribed treatments for ED and they generally should not be combined. One drug that has been studied in combination with PDE5 inhibitors is apomorphine. On its own, apomorphine has been shown to be more effective […]
Current research on ketamine and pain is focused on the use of this medication for managing treatment-resistant chronic neuropathic pain. Ketamine has shown promise as a treatment for chronic pain that can reduce the use of opioids and provide long-term benefits for patients. How Does Ketamine Treat Chronic Pain? Ketamine produces strong analgesia for neuropathic […]
There are many skin conditions that are difficult to treat. In some cases, treatments are available but they are painful, time consuming, expensive, or some combination of these. Topical immunotherapy is a technique that has been used for decades that has high treatment success rates. Despite the high rates of success, it continues to be […]
Dyclonine oral rinse is a popular topical anesthetic formulation with hygienists in particular. It can prevent a gag reflex in some patients, reduce pain from instrumentation, and provide pain relief before an injection. Dentists and hygienists who try dyclonine rinse with their patients are usually convinced that it should be an essential part of every […]